Posts Tagged ‘phospholipase’

Sicarius terrosus venom

Sicarius terrosus (six-eyed cave spider) is a highly toxic (and somewhat infamous) spider of the sicariidae family, whose bites, however rare, are characterised by significant necrotic pathology and potential mortality.  This is largely because of the presence of sphingomyelinase D in its venom[1], in the form of Phospholipase D StSicTox-betaIC1[2].  This has been shown to…

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Venom A to Z – B is for Basic phospholipase

Basic Phospholipase (PLA2) is a neurotoxic and haemotoxic enzyme common in Viper venoms, including rattlesnakes. Basic PLA2s, particularly those from Crotalus durrisus (pictured – C.durrisus vergrandis) have a wide range of therapeutic potenials for disease areas such as immunolgy, inflammation, infection, cancer and pain.

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