VENOM RESEARCH SOLUTIONS

Diverse Venom Array

Diverse crude venom arrayA diverse venom array is ideal for those projects or targets where there are no known venom leads and where a targeted approach is too risky. Crude venom can be used in circumstances where a biochemical (cell free) assay is available, as these assays are less sensitive to off-target effects. Each venom contains several hundred different components. Deconvolution takes longer, but still delivers useful tools for novel targets.

Description

Our Diverse Venom Array consists of 30 crude venoms in triplicate, from a phylogenetically and geographically diverse set of species. These venoms are selected to maximise hit potential on novel targets. As venom evolved independently in snakes, scorpions, spiders and centipedes, there is a large diversity of molecular classes. There is also diversity within groups. We include species from different continents and from different habitats, which powers natural selection in different ways.

This product is used as a pre-screen to inform the design of a Targeted Venom Discovery Array™ (T-VDA™).
T-VDAs use fractionated venoms to find closely related hits for potential structure-activity relationship studies.

Example Plate layout (1 mg/well)

Diverse Venom Array Species List

Code Species Group Family/sub-family
S.har Scolopendra hardwickei Centipede Scolopendridae
A.aus Androctonus australis Scorpion Buthidae
P.lio Parabuthus liosoma Scorpion Buthidae
H.ari Hadrurus arizonensis Scorpion Caraboctonidae
H.pau Hadogenes paucidens Scorpion Hemiscorpiidae
P.kra Protoiurus Kraepelini Scorpion Iuridae
H.swa Heterometrus swammerdami Scorpion Scorpionidae
O.scc Oxyuranus scutellatus canni Snake (taipan) Elapinae
N.mel Naja melanoleuca Snake (cobra) Elapinae
N.nig Naja nigricollis Snake (cobra) Elapinae
N.sia Naja siamensis Snake (cobra) Elapinae
D.pol Dendroaspis polylepis Snake (mamba) Elapinae
D.ang Dendroaspis angusticeps Snake (mamba) Elapinae
C.rho Calloselasma rhodostoma Snake (pit viper) Crotalinae
C.atr Crotalus atrox Snake (pit viper) Crotalinae
C.rru Crotalus ruber Snake (pit viper) Crotalinae
S.mil Sistrurus miliarius barbouri Snake (pit viper) Crotalinae
T.vog Trimeresurus vogeli Snake (pit viper) Crotalinae
M.xan Montivipera xanthina Snake (viper) Viperinae
B.grh Bitis gabonica rhinoceros Snake (viper) Viperinae
A.met Avicularia metallica Theraphosid Aviculariinae
T.cup Tapinauchenius cupreus Theraphosid Aviculariinae
E.pac Eucratoscelus pachypus Theraphosid Eumenophorinae
P.lug Pterinochilus lugardi Theraphosid Harpactirinae
H.lbo Cyriopagopus albostriatum Theraphosid Ornithoctoninae
P.for Poecilotheria formosa Theraphosid Poecilotheriinae
P.cam Psalmopoeus cambridgei Theraphosid Selenocosmiinae
H.mac Heteroscodra maculata Theraphosid Stromatopelminae
A.cor Acanthoscurria cordubensis Theraphosid Theraphosinae
T.str Theraphosa stirmi Theraphosid Theraphosinae

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