VENOM RESEARCH SOLUTIONS

Hit-to-Lead Services

Unlock the full potential of our Targeted Venom Discovery Arrays™ (T-VDAs) with this custom hit characterisation and lead optimisation service. The Venomtech team have decades of experience in global pharmaceutical drug discovery coupled with specialist knowledge of venoms and venomous animals. Using our industry-leading proprietary safe working practices we turn millions of years of evolution into the ultimate drug discovery pipeline. This starts with the T-VDA already optimised to provide biological tools in areas where synthetic chemistry has failed or where a biological is specifically sought.

1. Full identification of active component(s)

  • Characterisation of active fraction(s)
    • LC-MS, MALDI-TOF, MS/MS
  • Purification of single active(s)
    • For libraries not fully pre-fractionated
  • Resupply of actives for dose response testing
    • Milligram quantities purified from original venoms
  • Small scale synthesis of the pure active
    • Up to grams, either synthetic (<150 amino acids) or cloned for larger proteins
  • Large (up to 1kg) synthetic production (<150 amino acids), at GMP grade if needed, of single peptides

2. Hit-to-lead development

  • Provision of closely related targeted venoms to enhance potency and/or selectivity
  • Determination of structure-activity relationship (SAR)
  • Modifications for improved stability, delivery, bioavailability, etc
  • Toxicity testing, proof of concept and proof of mechanism in standard models

Available Products

Anti-inflammatory cosmetic skin Anti-inflammatory 
Cosmetic peptides to soothe skin and reduce inflammation
Antipollution 
Cosmetic peptides to protect skin from toxins and pollutants
VenomSELECTTM 
Our bespoke cosmetic peptide design service

 

Target-based 
Target-based venom arrays for hard-to-hit drug targets
Therapeutic areas 
Venom arrays for antimicrobial, pain, cancer research, etc.
Custom Arrays 
Venom arrays designed by us for your target or research area

 

Additional Resources

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