VENOM RESEARCH SOLUTIONS

Posts Tagged ‘Grammostolla porteri’

Need novel analgesics?

Once more the theraphosids (Tarantulas) have delivered novel tools for targeting pain relevant ion channels. A novel NaV1.7 blocking peptide has been identified from the species Grammostolla porteri (pictured). This peptide has 1000x fold selectivity over NaV1.5 and 20x over NaV1.4. However mutational analysis and structural analysis has allowed for modification to increase the NaV1.4…

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