DRUG DISCOVERY SOLUTIONS

Posts Tagged ‘pain’

Metrion Biosciences and Venomtech announce research collaboration

Collaboration to search for novel modulators of ion channels with proven therapeutic potential Cambridge, UK, 24 April 2017: Metrion Biosciences Limited (Metrion), the specialist ion channel CRO and drug discovery company, and Venomtech Limited (Venomtech) a biotechnology company with the UK’s largest venom library, today announced a collaboration agreement which will see the two companies…

Read More

Happy Birthday to Venomtech

We are excited to announce we are six years old. During those six years we have moved through three locations each time getting bigger and better. Now located in the amazing Discovery Park Community. We have shipped venoms to customers far and wide (USA, Europe, India and Australia). But most importantly we have facilitated work…

Read More

Novel pain and haematology tools from Vampire snails

New pharmacological tools from a haematophagus (Vampire) snail, Colubraria reticulata, have been discovered. these include anaesthetic peptides, haemostasis inhibitors and vasoconstriction modulators see paper. The authors note that fish appear to be semi anaethetised when the snail is in close proximity and this enables the snail to extend it’s probosis and collect the fishes blood.

Read More

Need novel analgesics?

Once more the theraphosids (Tarantulas) have delivered novel tools for targeting pain relevant ion channels. A novel NaV1.7 blocking peptide has been identified from the species Grammostolla porteri (pictured). This peptide has 1000x fold selectivity over NaV1.5 and 20x over NaV1.4. However mutational analysis and structural analysis has allowed for modification to increase the NaV1.4…

Read More

Venom A to Z – B is for Basic phospholipase

Basic Phospholipase (PLA2) is a neurotoxic and haemotoxic enzyme common in Viper venoms, including rattlesnakes. Basic PLA2s, particularly those from Crotalus durrisus (pictured – C.durrisus vergrandis) have a wide range of therapeutic potenials for disease areas such as immunolgy, inflammation, infection, cancer and pain.

Read More