DRUG DISCOVERY SOLUTIONS

Hit-to-Lead Services

Unlock the full potential of the Targeted Venom Discovery Arrays™ (T-VDAs) with this custom hit characterisation and lead optimisation service. The Venomtech team have decades of experience in global pharmaceutical drug discovery coupled with specialist knowledge of venoms and venomous animals. Using our industry-leading proprietary safe working practices we turn millions of years of evolution into the ultimate drug discovery pipeline. This starts with the T-VDA already optimised to provide biological tools in areas where synthetic chemistry has failed or where a biological is specifically sought.

1. Full identification of active component(s)

  • Characterisation of active fraction(s)
    • LC-MS, MALDI-TOF, MS/MS
  • Purification of single active(s)
    • For libraries not fully pre-fractionated
  • Resupply of actives for dose response testing
    • Milligram quantities purified from original venoms
  • Small scale synthesis of the pure active
    • Up to grams, either synthetic (<150 amino acids) or cloned for larger proteins
  • Large (up to 1kg) synthetic production (<150 amino acids), at GMP grade if needed, of single peptides

2. Hit-to-lead development

  • Provision of closely related targeted venoms to enhance potency and/or selectivity
  • Determination of SAR (structure-activity relationship)
  • Modifications for improved stability, delivery, bioavailability, etc
  • Toxicity testing, proof of concept and proof of mechanism in standard models

Molecular & Therapeutic Targeted Arrays

Ion channels venom

Ion Channels

New and exciting approaches to ion-channel pathways

GPCR's venom

GPCRs

Our peptides are unlocking GPCR targets in many applications

Kinases venom

Kinases

Our peptides are providing solutions for research into Kinases

Epigenetics venom

Epigenetics

Effective solutions for hard-to-hit epigenetic targets

Antimicrobial resistance venom

Antimicrobial Resistance

Our peptides are natural solutions for modulating resistant entities

S100 Proteins venom

S100 Proteins

We are hitting S100 targets

Resources: Supporting material to aid your research

Papers and Posters venom

Papers & Posters

Helpful Publications from our Team, our Partners and key Industry sources

News and events venom

News & Events

Up-to-date events and news items about the species, the science and our Team

People and partners venom

People & Partners

Find out more about our core and extended team, get in touch, collaborate!