DRUG DISCOVERY SOLUTIONS

Diverse Crude Venom Array

Diverse crude venom arrayA diverse crude venom array for those projects or targets where there are no known venom leads and where a targeted approach is too risky. Crude venom can be used in circumstances where a biochemical (cell free) assay is available, as these assays are less sensitive to off-target effects. Each venom contains several hundred different components and therefore deconvolution takes longer, but still delivers useful tools for novel targets.

Description

30 crude venom in triplicate, from a phylogenetically and geographically diverse set of species, selected to maximise hit potential on novel targets. As there is no common venomous ancestor between snakes, scorpions, spiders and centipedes, the diversity of molecular classes is large. The diversity continues within groups because we include species that originate from across the globe and from different habitats, both of which power natural selection in different ways. The diversity set is often used as a pre-screen to inform the design of a Targeted – Venom Discovery Array™ (T-VDA™) using fractionated venoms, and subsequently, to find closely related hits for potential Structural Activity Relationship (SAR) studies.

Example Plate layout (10 mg/well)

Full Crude Venom Array species list

Code Species Group Family/sub-family
S.har Scolopendra hardwickei Centipede Scolopendridae
A.aus Androctonus australis Scorpion Buthidae
P.lio Parabuthus liosoma Scorpion Buthidae
H.ari Hadrurus arizonensis Scorpion Caraboctonidae
H.pau Hadogenes paucidens Scorpion Hemiscorpiidae
P.kra Protoiurus Kraepelini Scorpion Iuridae
H.swa Heterometrus swammerdami Scorpion Scorpionidae
O.scc Oxyuranus scutellatus canni Snake (taipan) Elapinae
N.mel Naja melanoleuca Snake (cobra) Elapinae
N.nig Naja nigricollis Snake (cobra) Elapinae
N.sia Naja siamensis Snake (cobra) Elapinae
D.pol Dendroaspis polylepis Snake (mamba) Elapinae
D.ang Dendroaspis angusticeps Snake (mamba) Elapinae
C.rho Calloselasma rhodostoma Snake (pit viper) Crotalinae
C.atr Crotalus atrox Snake (pit viper) Crotalinae
C.rru Crotalus ruber Snake (pit viper) Crotalinae
S.mil Sistrurus miliarius barbouri Snake (pit viper) Crotalinae
T.vog Trimeresurus vogeli Snake (pit viper) Crotalinae
M.xan Montivipera xanthina Snake (viper) Viperinae
B.grh Bitis gabonica rhinoceros Snake (viper) Viperinae
A.met Avicularia metallica Theraphosid Aviculariinae
T.cup Tapinauchenius cupreus Theraphosid Aviculariinae
E.pac Eucratoscelus pachypus Theraphosid Eumenophorinae
P.lug Pterinochilus lugardi Theraphosid Harpactirinae
H.lbo Cyriopagopus albostriatum Theraphosid Ornithoctoninae
P.for Poecilotheria formosa Theraphosid Poecilotheriinae
P.cam Psalmopoeus cambridgei Theraphosid Selenocosmiinae
H.mac Heteroscodra maculata Theraphosid Stromatopelminae
A.cor Acanthoscurria cordubensis Theraphosid Theraphosinae
T.str Theraphosa stirmi Theraphosid Theraphosinae

Molecular & Therapeutic Targeted Arrays

Ion channels venom

Ion Channels

New and exciting approaches to ion-channel pathways

GPCR's venom

GPCRs

Our peptides are unlocking GPCR targets in many applications

Kinases venom

Kinases

Our peptides are providing solutions for research into Kinases

Epigenetics venom

Epigenetics

Effective solutions for hard-to-hit epigenetic targets

Antimicrobial resistance venom

Antimicrobial Resistance

Our peptides are natural solutions for modulating resistant entities

S100 Proteins venom

S100 Proteins

We are hitting S100 targets

Resources: Supporting materials to aid your research

Papers and posters venom

Papers & Posters

Helpful publications from our team, our partners and key industry sources

News and events venom

News & Events

Up-to-date events and news items about the species, the science and our team

People and partners venom

People & Partners

Find out more about our core and extended team, get in touch, collaborate!