Cosmetic Venom Peptides
Pollution and your skin
Pollution, from cars, factories and power stations, contains heavy metal microparticles such as lead, zinc and cadmium. These pollutants build up in city air and stick to skin. Studies have shown that these heavy metal microparticles increase signs of ageing, including dark spots, wrinkles and dullness. Protecting skin from these toxins is an important step towards younger-looking, vibrant skin.
Lionfish (Pterois spp.) are successful tropical reef fish that are quick to colonise new reefs. These magnificent, venomous fish have a secret to their success; they can cope with toxins from marine pollution. Toxic substances, including heavy metals and organochlorides, bind to proteins in the Lionfish and are held away from their skin. These same toxins are found in polluted city air and can accumulate on human skin.
LioPep-5™ is a biologically active peptide from the lionfish that collects zinc and other metal ions. Moisturisers could be formulated to protect skin by binding to the ions and isolating them. Scrubs, cleansers and face washes could be formulated to remove these toxins from skin. LioPep-5™ has been shown to reduce zinc by up to 89%.
Carpet vipers (Echis spp.) are venomous snakes found across northern Africa, the Middle East and South Asia. Their venom contains toxins that damage skin proteins and harm healthy tissues. These toxins are so potent that carpet vipers have evolved peptides to protect themselves from their own venom. Venomtech, have synthesised the defensive peptides, to create ViPep-5™.
ViPep-5™ is a biologically active peptide derived from carpet viper venom. Moisturisers, could be formulated from ViPep-5™ to protect skin from metal ions and other toxins. A face wash or scrub could be formulated to remove these pollutants from skin. ViPep-5™ has been shown to reduce the amount of zinc by up to 87%.
Many everyday chemicals can irritate skin, causing unsightly redness and inflammation. These irritants kick start the inflammatory process in our skin, involving activities from enzymes such as Phospholipases. One such enzyme phospholipase A2, (aka, PLA2) releases inflammatory mediators in the skin. Blocking this activity reduces redness and inflammation.
Swallowtail butterflies (Papilio spp.) are found throughout all the world’s continents. These butterflies’ delicate anatomies hide a powerful biochemical physiology that has evolved to protect them in the many hostile environments that they encounter. These adaptations include anti-inflammatory proteins to protect their fragile wings from inflammation and damage.
MorphoClenseTM has been shown, in-vitro, to achieve a 73% reduction in PLA2 activity. MorphoClenseTM is non-toxic to human cells in culture, water soluble and amenable to many formulations. Suggested formulations include washes, cleansers and scrubs with claims for reducing redness and irritation.
Bark scorpions (Centruroides spp.) are found mainly in North and Central America and into South America. The venom from these scorpions contains active inflammatory proteins, including PLA2. To protect themselves from the inflammatory action of this protein, the scorpions have evolved inhibitory peptides. ScorpSootheTM replicates the effects of these inhibitors to soothe skin.
The ScorpSoothe™ tetra peptide reduces PLA2 activity by 55% in-vitro. This peptide is non-toxic to human cells in culture, water soluble and is amenable to many formulations. This includes such products as moisturisers, cleansers and foundation. Suggested claims could include reducing redness and skin irritation.