Cosmetic Actives Development
Delivering Innovative Cosmetic Actives
Our Venom peptide library offers many ways to achieve commercially valuable cosmetic actives - providing a high degree of control and risk reduction. We can lead on part or all of the following process:
- Identify molecular target for desired effects
- Select venom peptide to interact with target
- Test for efficacy and potency
- Re-design and optimize peptide
- Safety testing and Registration
- Bulk supply of actives
Product Preservative or Antibiotic actions
Venomous animals have had to evolve novel ways of protecting themselves from
Infections, thus venoms have evolved a wide range of antimicrobial actions. These
include antibacterial and anti fungal effects. Our scientists can tailor the venom peptide to specifically meet your needs for product stability right through to skin cleansing and even balancing native flora for healthier skin.
Ion Channels present in the nerve terminals of the skin are involved with the perception
skin sensitivity. Activation of these channels directly increases skin sensitivity, pain and
other unpleasant sensations. Venoms from spiders and scorpions are known that block
these ion channels such as Acid Sensing Ion Channels (ASICS) and Calcium
Channels. Venom-derived peptides can be designed to block these receptors in a
Enzymes such as proteases break down collagen, elastin and other structural
proteins that maintain the skins flexibility and prevents wrinkle formation. Centipede venoms
contain a diverse collection of widely unexplored proteins, some of which are known to have
protease inhibiting properties. c-jun is a transcription factor that is expressed at higher levels
in aged skin, and controls the expression of many genes involved in skin ageing. Scorpion
venom peptides are known to inhibit c-jun and may therefore reduce ageing. Some snake
Venoms actively remodel skin proteins (for exfoliation, scar reduction and/or anti-ageing).
Arises from many daily activities, and is the result of a loss of moisture
(Transepidermal Water Loss; TEL) and micronutrients from the skins surface.
Many moisturisers focus on replacement of these lost factors. However venoms
from desert creatures such as spiders, scorpions and centipedes can stop
moisture loss from occurring through modulation of key ion channels (aquaporins)
involved in water loss.
A tool to aid in identifying novel venom-derived cosmetic actives
Our main cosmecuetical offering, VenomSELECTTM serves to identify and characterise novel peptide cosmetic actives in animal venoms (and also algae) for use as cosmecueutical active ingredients for a wide range of cosmetic claims.
Case Study: SensAmone P5 (developed using our VenomSELECT service).
Venom Cosmetic Claims