Cosmetic Active Ingredient Development
Cosmetic Actives Development
Delivering innovative cosmetic actives
The last decade has seen significant growth in the use of active peptides to produce superior functional cosmetics, sometimes called cosmeceuticals (an amalgamation of cosmetic and pharmaceutical). It is well known that venoms contain a wide range of biologically active peptides, and several venoms have demonstrated functional activity in cosmetics. Products containing bee venom (whole and individual peptides) were the first on the market in early 2000s followed by a short synthetic snake venom peptide in 2009.
Prior to Venomtech’s involvement in the industry, venom-based cosmetics were restricted to anti-wrinkle and anti-ageing indications.
Through our VenomSELECT™ service we have opened up possibilities for novel, functional, active ingredients, from venoms for all indications. Our first product is SensAmone P5, a synthetic pentapeptide, derived from Sea Anemone venom. This product reduces the pain of sensitive skin by blocking TRPV1 in-vitro and has been shown to reduce pain sensation in human volunteers.
We can help deliver your next premium active ingredient, with data to support your claims.
Our venom peptide library offers many ways to achieve commercially valuable cosmetic actives, providing a high degree of control and risk reduction. We can lead on part or all of the following process:
- Identifying molecular targets for desired effects
- Selecting venom peptides to interact with targets
- Testing for efficacy and potency
- Re-designing and optimising peptides
- Safety testing and registration
- Bulk supply of actives
Please see our VenomSELECT™ page for further details.
Venomous animals have had to evolve novel ways of protecting themselves from infections.
Venoms have evolved a wide range of antimicrobial actions, including antibacterial and
anti fungal effects. Our scientists can tailor the venom peptide to specifically meet your needs,
from product stability, right through to skin cleansing and even balancing native flora for
Ion Channels present in the nerve terminals of the skin are involved with the perception
skin sensitivity. Activation of these channels directly increases skin sensitivity, pain and
other unpleasant sensations. Venoms from spiders and scorpions are known that block
these ion channels such as Acid Sensing Ion Channels (ASICS) and Calcium
Channels. Venom-derived peptides can be designed to block these receptors in a
Enzymes such as proteases break down collagen, elastin and other structural
proteins that maintain the skins flexibility and prevents wrinkle formation. Centipede venoms
contain a diverse collection of widely unexplored proteins, some of which are known to have
protease inhibiting properties. c-jun is a transcription factor that is expressed at higher levels
in aged skin, and controls the expression of many genes involved in skin ageing. Scorpion
venom peptides are known to inhibit c-jun and may therefore reduce ageing. Some snake
Venoms actively remodel skin proteins (for exfoliation, scar reduction and/or anti-ageing).
Arises from many daily activities, and is the result of a loss of moisture
(Transepidermal Water Loss; TEL) and micronutrients from the skins surface.
Many moisturisers focus on replacement of these lost factors. However venoms
from desert creatures such as spiders, scorpions and centipedes can stop
moisture loss from occurring through modulation of key ion channels (aquaporins)
involved in water loss.