DRUG DISCOVERY SOLUTIONS

Cosmetic Actives Development

icon_cosmetics

Delivering Innovative Cosmetic Actives

Our Venom peptide library offers many ways to achieve commercially valuable cosmetic actives - providing a high degree of control and risk reduction. We can lead on part or all of the following process:

  1. Identify molecular target for desired effects
  2. Select venom peptide to interact with target
  3. Test for efficacy and potency
  4. Re-design and optimize peptide
  5. Safety testing and Registration
  6. Bulk supply of actives

Cosmetic Applications

Product Preservative or Antibiotic actions venomProduct Preservative or Antibiotic actions

Venomous animals have had to evolve novel ways of protecting themselves from
Infections, thus venoms have evolved a wide range of antimicrobial actions. These
include antibacterial and anti fungal effects. Our scientists can tailor the venom peptide to specifically meet your needs for product stability right through to skin cleansing and even balancing native flora for healthier skin.

Hyper-sensitive Skin venomHyper-sensitive Skin

Ion Channels present in the nerve terminals of the skin are involved with the perception
skin sensitivity. Activation of these channels directly increases skin sensitivity, pain and
other unpleasant sensations. Venoms from spiders and scorpions are known that block
these ion channels such as Acid Sensing Ion Channels (ASICS) and Calcium
Channels. Venom-derived peptides can be designed to block these receptors in a
controlled mannor.

Skin ageing venomSkin Ageing

Enzymes such as proteases break down collagen, elastin and other structural
proteins that maintain the skins flexibility and prevents wrinkle formation. Centipede venoms
contain a diverse collection of widely unexplored proteins, some of which are known to have
protease inhibiting properties. c-jun is a transcription factor that is expressed at higher levels
in aged skin, and controls the expression of many genes involved in skin ageing. Scorpion
venom peptides are known to inhibit c-jun and may therefore reduce ageing. Some snake
Venoms actively remodel skin proteins (for exfoliation, scar reduction and/or anti-ageing).

Dry skin Aquaporin venomDry Skin

Arises from many daily activities, and is the result of a loss of moisture
(Transepidermal Water Loss; TEL) and micronutrients from the skins surface.
Many moisturisers focus on replacement of these lost factors. However venoms
from desert creatures such as spiders, scorpions and centipedes can stop
moisture loss from occurring through modulation of key ion channels (aquaporins)
involved in water loss.

VenomSELECT

A tool to aid in identifying novel venom-derived cosmetic actives

Our main cosmecuetical offering, VenomSELECTTM serves to identify and characterise novel peptide cosmetic actives in animal venoms (and also algae) for use as cosmecueutical active ingredients for a wide range of cosmetic claims.

Venom derived cosmetics

Case Study: SensAmone P5 (developed using our VenomSELECT service).

Mibelle biochemistry venom

In partnership with Mibelle Biochemistry (a Swiss company, that specialises in the research and development of innovative, high-quality actives for the cosmetic industry) we identified target - TrpV1 as a target for soothing sensitive skin, identified a venom peptide from H. crispa sea anemone, that had a high probability of hitting the target, and designed and synthesised short peptides that mimicked the active site of the full length peptide. After synthesising the peptides, we tested them for efficacy and potency, optimized the best of them, generated a 5 amino acid peptide and retested it in a cell-based assay. Following clinical studies, Venomtech provided pre- and post launch marketing and scientific support.

 

Venom Cosmetic Claims

Venom cosmetic

Molecular & Therapeutic Targeted Arrays for Cosmetics

Ion channels venom

Ion Channels

New approaches to ion-channel pathways

GPCR's venom

GPCRs

Our peptides are unlocking GPCR targets in many applications

Kinases venom

Kinases

Our peptides are providing solutions for research into Kinases

Epigenetics venom

Epigenetics

Effective solutions for hard-to-hit epigenetic targets

Antimicrobial resistance venom

Antimicrobial Resistance

Our peptides are natural solutions for modulating resistant entities and controlling pests

S100 Proteins venom

S100 Proteins

We are hitting S100 targets

Cosmetic & Cosmeceutical Resources

Papers and Posters venom

Papers & Posters

Helpful publications from our team, our partners and key industry sources

News and events venom

News & Events

Up-to-date events and news items about the species, the science and our team

People and partners venom

People & Partners

Find out more about our core and extended team, get in touch, collaborate!