Enabling Breakthroughs in Bio-Insecticide Discovery
Venom peptides are proving effective against pest organisms - offering alternatives to traditional approaches to bio-insecticide discovery and development.
nAChR, GABA and GluCl Targeted Arrays
Venom Bio-Insecticide Discovery Options
Chemical insecticides usually act on a small number of molecular targets (e.g. nAChR channels, Gaba-gated Cl- channel, Glutamate-gated Cl- channel [GluCls]) and are therefore highly selective for insect pests. As a result, hundreds of species of insects have developed resistance to one or more classes of these insecticides. This development of insecticide resistance and concerns about environmental and human safety has resulted in a demand for new environmentally sustainable insecticidal active ingredients with novel modes of action.
In contrast, venoms have a broad spectrum of insect-killing, and immobilising abilities that have evolved to avoid the development of resistance. At Venomtech we offer a number of unique approaches to development of bio-insecticides from venom:
- Venom toxin purification service – We can purify your selected toxin from venoms in our library
- T-VDAInsect – screen our venom array to identify novel leads for your traditional insecticide targets or discover novel targets
- Venom formulation – create your own novel venom mimic from mixtures of purified venom components
Bio-Insecticide activity of Venomtech crude venom preparations on Diptera larvae.
Percentage lethality of the 30 crude venom diversity set.
The venom diversity set is an effective tool for finding novel insecticide activity; 12 of the 30 venoms tested were active at one hour.