DRUG DISCOVERY SOLUTIONS

Bio-Insecticide Discovery

icon_insecticides

Enabling Breakthroughs in Bio-Insecticide Discovery

Venom peptides are proving effective against pest organisms - offering alternatives to traditional approaches to bio-insecticide discovery and development.

nAChR, GABA and GluCl Targeted Arrays

Venom Bio-Insecticide Discovery Options

Chemical insecticides usually act on a small number of molecular targets (e.g. nAChR channels, Gaba-gated Cl- channel, Glutamate-gated Cl- channel [GluCls]) and are therefore highly selective for insect pests. As a result, hundreds of species of insects have developed resistance to one or more classes of these insecticides. This development of insecticide resistance and concerns about environmental and human safety has resulted in a demand for new environmentally sustainable insecticidal active ingredients with novel modes of action.

Bio-insecticide venom

In contrast, venoms have a broad spectrum of insect-killing, and immobilising abilities that have evolved to avoid the development of resistance. At Venomtech we offer a number of unique approaches to development of bio-insecticides from venom:

  • Venom toxin purification service – We can purify your selected toxin from venoms in our library
  • T-VDAInsect – screen our venom array to identify novel leads for your traditional insecticide targets or discover novel targets
  • Venom formulation – create your own novel venom mimic from mixtures of purified venom components

Bio-Insecticide activity of Venomtech crude venom preparations on Diptera larvae. 

Percentage lethality of the 30 crude venom diversity set.

Bio-Insecticide activity crude venom preparations on Diptera larvae

The venom diversity set is an effective tool for finding novel insecticide activity; 12 of the 30 venoms tested were active at one hour.

 

Molecular & Therapeutic Targeted Arrays for Crop Science

Ion channels venom

Ion Channels

New and exciting approaches to ion-channel pathways

GPCR's venom

GPCRs

Our peptides are unlocking GPCR targets in many applications

Kinases venom

Kinases

Our peptides are providing solutions for research into Kinases

Epigenetics venom

Epigenetics

Effective solutions for hard-to-hit epigenetic targets

Antimicrobial resistance venom

Antimicrobial Resistance

Our peptides are natural solutions for modulating resistant entities

S100 Proteins venom

S100 Proteins

We are hitting S100 targets

Insecticide & Crop Science Resources

Papers and posters venom

Papers & Posters

Helpful publications from our team, our partners and key industry sources

News and events venom

News & Events

Up-to-date events and news items about the species, the science and our team

People and partners venom

People & Partners

Find out more about our core and extended team, get in touch, collaborate!